DOUBLE MARKER FIRST TRIMESTER 8-13 WEEKS (FMF CERTIFIED)

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DOUBLE MARKER FIRST TRIMESTER 8-13 WEEKS (FMF CERTIFIED)

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Double Marker – First Trimester is a simple screening test recommended to all pregnant women in the first trimester. The test evaluates the risk of some genetic/chromosomal abnormalities in the growing baby. It is performed during 9-14 weeks of pregnancy. The profile includes 2 parameters – beta human chorionic gonadotropin and pregnancy-associated plasma protein A. Genetic abnormalities like Trisomy and Down syndrome cause permanent mental retardation and other medical illnesses.

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Routine hematology and coagulation testing is available 24 hours a day, 7 days a week. Additionally, advanced hematological tests are a performed using a variety of techniques including flow cytometry and electrophoresis based methods and are available from Monday to Friday, 7 am – 5 pm.

1
Maternal serum Free beta HCG assessment between 9-13 weeks, has significant utility in first Trimester Prenatal Screening for Down Syndrome and other chromosomal anomalies. This test also helps in the diagnosis and monitoring of Trophoblastic diseases and certain Testicular tumors where ratio of Free beta HCG to Total HCG is high. Some tumors secrete only free beta HCG and virtually no Total HCG is detected.
2
Pregnancy Associated Plasma Protein–A (PAPP-A) is secreted by placenta and levels elevate with gestational age. It is also expressed by a variety of tissues, but at much lower levels. Unstable or ruptured coronary artery plaques, but not stable plaques also express PAPP-A. This test is used for First Trimester Prenatal Screening.

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